AFP and spinocerebellar ataxia type 1: The index patient was also assessed by extensive serum testing for biomarkers indicative of recessive ataxias (alpha-fetoprotein, lactate, vitamin E, very long fatty acids, phytanic acid, coeruloplasmin, cholesteanol, lysosomal enzymes, quantitative assessment of amino acids) [14], and genetic testing for SCA1,2,3,6,7 was performed.