In order to validate these data, inductively coupled plasma mass spectrometry (ICP-MS) showed that after 5 days of treatment, only anti-Kras nanobeacons accumulate extensively in tumor tissue; whereas both anti-Kras and nonsense nanobeacons accumulate in lung tissue (with a 5-fold increase when compared to other organs, such as heart, liver, spleen, kidney – Fig. 4C). Here, KRAS is linked to neoplasm.