Therefore, we designed and developed an in vivo universal tool based on AuNPs functionalized with a dye labeled hairpin-DNA, i.e. gold-nanobeacon to inhibit simultaneously cancer cells and metastasis in a murine tumor model following systemic administration via the antisense silencing of a mutant transcript of Kras gene (see Fig. 1A). The gene discussed is KRAS; the disease is neoplasm.