After incubation of primary leukemia blasts with DMSO, Ox-1, or ZM, and/or ABT-263 for 24h, Annexin V-FITC staining shows that Ox-1 or ZM alone induces minimal apoptosis, but in combination with ABT-263 significantly enhances cell death via apoptosis in primary blasts. Here, ANXA5 is linked to leukemia.