TP53 and cancer: As cell detachment and cell shrinking are ubiquitous aspects of apoptosis [39], we examined these features in four cancer cell lines: HCT116 (WT-p53), LoVo (WT-p53), SW-480 (mutant-p53), and U2OS (WT-p53), all in the presence of vehicle (DMSO, Supplementary Figure S1D), and different concentrations of VTD (Figure 4, Supplementary Figure S4).