Expectedly, VTD significantly decreases the number of colonies of LoVo (Figure 4H and Supplementary Figure S4E), HepG2 (liver cancer cell line, Figure 4I), and U2OS (Figure 4J) with as low as 30 μM VTD concentration, while SW480 cells with mutant p53 had no response to VTD, even at higher doses (Figure 4K). Here, TP53 is linked to liver cancer.