A few works have been published using only murine models, showing that CXCL14 is expressed by activated microglia after induction by GBM conditioned medium [24]; our finding of CXCL14 increased expression in STCs compared to STPs may reflect a higher level of microglial or more probably reactive astrocyte infiltration in ST tumor centers compared to peritumor areas, which, on the contrary, doesn't characterize LT tumor centers when compared to their own peritumor areas. This evidence concerns the gene CXCL14 and glioblastoma.