IGFBP5 and retinoblastoma: Interestingly, when we compared the peripheral areas of ST vs LT patients, we found the overexpression (Log2FC STP vs LTP = 1.6, p = 0.0178) of IGFBP5, encoding for insulin-like growth factor binding protein 5, previously shown to be expressed by activated astrocytes in retinoblastoma, where they cooperate with tumor cells to promote tumorigenesis [36].