Two mRNAs whose expression characterizes LTCs vs LTPs, LRFN3 (encoding for Leucine Rich repeat and Fibronectin type III domain containing 3) and NR2F6 (Nuclear Receptor subfamily 2 group F member 6), were previously included in the “classical” signature of glioblastoma [13]. This evidence concerns the gene LRFN3 and glioblastoma.