The overexpressed RNA molecules were slightly more (i.e. 21, Table 2b, p value < 0.05) than the underexpressed ones, and included microvascular, proliferation and survival markers of GBM, such as COL4A1 and TOP2A [21, 22], ECM molecules, as NID1 [23], markers of activated microglia, as CXCL14 [24], and RNAs characterizing the “classical” glioblastoma subtype, such as RGS12 and SOCS2 [13], also expressed in activated astrocytes [25], or even the “mesenchymal” subtype, such as TGFBI [13]. Here, TOP2A is linked to glioblastoma.