Mir-183, that we found to characterize most of our samples and also to distinguish the infiltrated vs the non-infiltrated peritumoral areas, is a TGFβ-induced miRNA previously reported to suppress tumor-associated natural killer cells, thus explaining one of the ways through which TGFβ plays its immunosuppressive roles in tumor microenvironment [57]. This evidence concerns the gene TGFB1 and neoplasm.