In conclusion, this comprehensive study of GBM tissues and peritumoral areas indicates some key molecules characterizing LT from ST tissues, and at the same time shows the commonality of some molecules and pathways (e.g. TGFβ) between tumor centers and peritumoral areas, strongly suggesting that such molecules/pathways should be targeted in both areas in order to fight, and defeat, glioblastoma. This evidence concerns the gene TGFB1 and neoplasm.