MAPK8 and neoplasm: Subsequent analysis showed that cooperation depended upon activation of the JNK and downregulation of the Hippo negative tissue growth control pathways, thereby promoting tumour growth, inhibiting differentiation and promoting an invasive phenotype (Doggett et al., 2011; Igaki et al., 2006; Leong et al., 2009; Uhlirova and Bohmann, 2006; Uhlirova et al., 2005).