LYVE1 and neoplasm: The results showed that NCTD, not only as mF4-31C1 in vitro [14, 23, 26, 35], inhibited the lymphatic tube formation of the 3-D culture of HDLECs and the co-culture system by suppressing proliferation, migration, invasion, and inducing apoptosis, as Sorafenib in vivo [37, 38, 62], inhibited tumor growth and lymphangiogennesis of in-situ colonic xenografts with a prolonged survival time (log-rank test, P = 0.026), but also downregulated the expression of LYVE-1, D2-40 and CK20 proteins/mRNAs, decreased the LMVD numbers in the in-situ colonic xenografts.