FLT4 and neoplasm: In the experiment, on the base of our recent report in which NCTD suppressed lymphangiogenesis in human LECs [23], we further investigate the effect of NCTD on tumor lymphangiogenesis, and present evidence that NCTD inhibits tumor growth and lymphangiogenesis of HCACs by downregulating VEGF-C,-D/VEGFR-3 and VEGF-A/VEGFR-2 signaling pathways.