KDR and neoplasm: Because there is a crosstalk between angiogenesis and lymphangiogenesis in tumor progression, we thus deduce that NCTD inhibits tumor growth and lymphangiogenesis of HCACs, as mF4-31C1 or Sorafenib through directly downregulating the VEGF-C, −D/VEGFR-3 signaling pathway, or similar to Sorafenib through indirectly downregulating the VEGF-A/VEGFR-2 signaling pathway.