VEGFD and neoplasm: Recently, VEGF-C, VEGF-D and their cognate receptor VEGFR-3 located on LECs and the VEGF-C, −D/VEGFR-3 signaling pathway are believed to be the most important lymphangiogenic growth factors and the most pivotal mechanism underlying tumor lymphangiogennesis [20, 25, 28, 37, 39].