The highly elevated serum IgE level in HIV patients with helminths co-infection in the current study might be a result of HIV-helminths induced immune dysregulation which provoke a shift in cytokine production from Th1 to Th2 [5, 30] and the resulting polyclonal activation of B cells which increase secretion of IgE [31, 32]. This evidence concerns the gene IGHE and coinfection.