In a recent study by Toffalorio et al. [25], among patients with wild-type EGFR NSCLC, 13 patients with high polysomy of chromosome 7 received erlotinib, in which the disease control rate was as high as 76.9% (1 patient with complete response, 4 patients with partial response, and 5 patients with stable disease); the mean time-to-progression in this subpopulation was 9 months, suggesting a potential role of high polysomy of chromosome 7 as a useful biomarker to identify patients harboring wild-type EGFR mutations who may benefit from EGFR-TKIs. Here, EGFR is linked to non-small cell lung carcinoma.