EGFR and non-small cell lung carcinoma: Moreover, a recent meta-analysis including 1,605 patients with wild-type EGFR NSCLC in 11 trials demonstrated that chemotherapy showed a superiority in terms of PFS (HR, 1.84; 95% CI, 1.35–2.52) and ORR (16.8 versus 7.2%; relative risk, 1.11; 95% CI, 1.02–1.21) compared with EGFR-TKIs [21].