A positive staining of cancer tissues with the TKTL1-specific antibody clone JFC12T10 was reported to correlate with a poor patient outcome in some cancer entities including laryngeal squamous cell carcinoma, non small cell lung cancer, tumors of the ocular adnexa, papillary thyroid carcinoma and rectal cancer, indicating TKTL1 as a marker of prognostic relevance [15, 19, 23, 24, 35]. The gene discussed is TKTL1; the disease is differentiated thyroid carcinoma.