It has been also reported that Hsf4 mutations may also be associated with age-related cataract [9] and mutations in the DNA binding domain (A20D, I87V, L115P, R120C and R74H) of Hsf4 cause autosomal dominant cataract [7, 10, 11]. This evidence concerns the gene HSF4 and Autosomal dominant optic atrophy and cataract.