Therefore, individuals with genetic polymorphisms associated to STAT3 who are colonized by CagA strains with higher number of EPIYA-C segments are most likely to benefit from H. pylori eradication aiming to prevent gastric cancer as it has been recommended by the IARC working group on Helicobacter pylori eradication as a strategy for preventing gastric cancer. This evidence concerns the gene S100A8 and gastric cancer.