Some previous studies argued that differences in the CD56 expression may affect migration of tumor cells; Kim et al reported that Homeobox 9 (a transcription factor) regulates transcription of CD56 in PTCs and Scarpino et al described that CD56 in PTCs may cause down-regulation of vascular endothelial growth factors D and C (VEGF-D and VEGF-C) which stimulate lymphangiogenesis [23, 38]. This evidence concerns the gene NCAM1 and neoplasm.