MYC and Miyoshi myopathy: Pims are constitutively expressed uniquely in the hematologic malignancies and Pim-2 expression is higher in MM than in any other cancer or in physiology.1 Established roles for the Pim kinases in MM are diverse and include MM proliferation,1 survival,2 cell cycle dysregulation,3, 4 an oncogenic collaboration with the most frequently dysregulated gene in MM (Myc)5, 6 and mediating bone destruction.7 Putative roles include mediating drug resistance, migration and homing of MM cells.