An emerging role for Pim-2 in the bony destruction and marrow expansion of MM has been reported.7 Pim-2 is seen to negatively regulate osteoblastogenesis in murine cell line models, with the effect reversed on Pim-2 knockdown or pharmacological inhibition.7 The chief osteoblastogenic effects mediated by Pim inhibition were increase of osteoblastogenic factor bone morphogenetic protein-2 (BMP-2) and reduced transforming growth factor β signaling. The gene discussed is PIM1; the disease is Miyoshi myopathy.