In vitro work in MM cell lines revealed cytotoxicity in Pim2-dependent MM by inhibiton of mTORC1 with reduced phosphorylation of 4EBP1 and S6K; promoting apoptosis with inhibition of BAD phosphorylation and cleavage of PARP and caspases 3, 7, 8 and 9; and cell cycle arrest at G0/G1. Here, CASP3 is linked to Miyoshi myopathy.