In B-cell lymphoproliferative malignancies, Pim-2 has a dominant role by regulating mTORC1, as evidenced by reduced phospho-4EBP1 with Pim inhibition.38 In chronic lymphocytic leukemia, Pim inhibition at concentrations sufficient to reduce MYC and MCL1 expression affects cell death, whereas antiapoptotic effects were not affected at this level. Here, PIM1 is linked to B-cell chronic lymphocytic leukemia.