TLR4 and stroke disorder: Because the upregulation of CB2R, IBA1, and TLR4 occurred between days 2 and 5 post-stroke, we next treated animals with the CB2R agonist AM1241 (2.5 mg/kg/d) [30], the anti-inflammatory agent pioglitazone (1 mg/kg/d) [31], or vehicle from days 2 to 5.