These results are in contrast with those described in a prior study that focused on high-stage tumors.13 In their study, Yoon et al13 reported that only 17% of 713 esophageal adenocarcinomas were Her-2 positive and that Her-2 positivity was significantly associated with lower tumor grade, less invasive tumors, fewer malignant lymph nodes, and the presence of adjacent BE. Here, ERBB2 is linked to esophageal adenocarcinoma.