Their study showed a moderate to strong membranous Her-2 staining pattern and higher rate of Her-2 tumor heterogeneity in gastric adenocarcinoma as compared with breast cancer.10 In esophageal cancer and its precursor lesions including BE, data on Her-2 amplification and overexpression frequency are limited and correlation investigations between Her-2 amplification and prognosis have shown conflicting results.11–13. Here, ERBB2 is linked to esophageal cancer.