In these studies, it was shown that the frequency of p65 nuclear distribution, as evaluated by IHC in prostatic tumor cells, was correlated with either Gleason score, presence of lymph node metastasis, seminal vesicle invasion or with surgical margins [8, 24, 25, 39, 41]. The gene discussed is RELA; the disease is metastatic malignant neoplasm in the lymph nodes.