IGHG3 and autoimmune polyendocrinopathy: In contrast, IgG2 dominated the subclass profile for NHD (46%; IgG2 > IgG1, IgG2 > IgG3, and IgG2 > IgG4 (p < 0.0001)) and patients with APS (38%; IgG2 > IgG1 (p < 0.0001), IgG2 > IgG3 (p = 0.001)).