Patients with APS (PAPS and SAPS) showed significantly higher OD values for anti-β2GP1-IgG1, -IgG2, and -IgG3 than NHD (Figures 2(a), 2(b), and 2(c); Table 3(b)). The gene discussed is IGHG3; the disease is autoimmune polyendocrinopathy.