PPARG and obesity due to melanocortin 4 receptor deficiency: It is important to highlight that we are the first group reporting that 12Ala/Ala genotype carriers show increase in adiposity indexes, such as conicity and abdominal volume indexes and total adipose area, which are indicative of abdominal obesity, along with a difference in the distribution of Pro12Ala in PPARG2 polymorphism among subjects with obesity when compared to nonobese subjects.