The supplementary analysis where we compare the carriers of different genotypes in PPARG2 polymorphism, according to their classification by BMI, in groups with normal range and pre-obesity, showed no difference, except for HDLc levels in subjects with preobesity, while in the carriers of the phenotype Ala+ in obese group, an increase in metabolic markers was observed. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.