PPARG and type 2 diabetes mellitus: PPARG2 is located on chromosome 3 and its polymorphism Pro12Ala, rs1801282 is located in exon B. In vitro analyses on its functionality have shown controversial results regarding the 12Ala allele and the reduction in the transcriptional activity of PPARG2, while the polymorphism's involvement in T2DM is reported in several studies [13, 18–20].