Studies on both overweight and obese women have found that serum TNFα and IL-6 levels were positively correlated [48] while Ozay et al. [35] found that HFD-induced obesity in male Wistar albino rats (22% fat for 12 weeks) increased plasma TNFα without altering plasma IL-6. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.