Autoxidation of sickle hemoglobin (HbS) along with repeated cycle of sickling and unsickling cause premature destruction of erythrocytes and generation of reactive oxygen species (ROS) leading to oxidative stress.1 This is evidenced in the present study which shows low level of antioxidants (such as Vit C, Vit E, albumin, GSH) and high level of oxidants (such as 8OHdG, MDA) in SCD patients compared to normal individuals. Here, ALB is linked to Schnyder corneal dystrophy.