There were no difference among the SCD patients with and without mutations in hOGG1 326Cys and XRCC1 280His alleles with respect to yearly incidence of chest pain, bone joint pain, fatigue, fever, blood transfusion along with degree of splenomegaly and age onset of disease (Table 4). The gene discussed is XRCC1; the disease is Schnyder corneal dystrophy.