The lower level of antioxidants particularly Vit C, Vit E, albumin, GSH along with higher level of LDH, low level of hemoglobin in this study are supported by earlier findings in SCD patients.13 The high level of MDA in SCD patients observed in the present study is similar to earlier observation of higher level of MDA produced in related hemoglobinopathy patients particularly beta thalassemia patients of India.14 Oxidative products such as MDA and 8-OHdG are known to be mutagenic and cause damage to DNA. This evidence concerns the gene ALB and beta thalassemia.