Recent studies have explained the role of different chemokines in cellular and molecular pathophysiology of BD [7], and, in particular, interleukin-1 (IL-1) cytokine family is described to play a complex network of minor proinflammatory mediators and subsequent expression of integrins on leukocytes and endothelial cells, with many influences on the inflammatory response [78]. The gene discussed is IL1B; the disease is Behcet disease.