IL1B and Behcet disease: Lately, the recombinant human IL-1 receptor antagonist (anakinra), the human immunoglobulin G1 (IgG1) anti-IL-1 beta monoclonal antibody (canakinumab), and the recombinant humanized anti-IL-1 beta antibody (gevokizumab) are proven to be partially useful in the treatment of BD, while appearing to be more effective in ocular involvement [22].