To further confirm the contribution of the AMR in Fc-independent anti-GPIbα antibody-mediated thrombocytopenia, we first injected anti-GPIbα mAbs into FcγR−/− mice and found thrombocytopenia still occurred (Fig. 6c), particularly when injected with anti-GPIbα mAb NIT G (Supplementary Fig. 7a), while anti-GPIIbIIIa mAbs failed to induce a significant decrease in platelets in these mice (Fig. 6d). The gene discussed is FCGR2A; the disease is Thrombocytopenia.