MiR-135b-5p was highly influenced by ACE inhibitors and statin treatment was significantly associated with increased levels of circulating miR-499a-3p (Supplementary Table S3); however, when only atherosclerotic patients were included in the analysis, hypertension was inversely correlated with the levels of circulating miR-499a-3p and none of the other factors remained a significant factor (Supplementary Table S4). The gene discussed is ACE; the disease is Hypertension.