STAT3 and neoplasm: They found that ATX inhibited key events in JAK-2/STAT-3 signaling especially STAT-3 phosphorylation and subsequent nuclear translocation of STAT-3, leading to down-regulated of STAT-3 target genes involved in cell proliferation (cyclin D1, PCNA), invasion and angiogenesis (MMP-2, MMP-9) and angiogenesis (VEGF, VEGFR2), resulting in inhibition of tumor development and progression.