Importantly, the down-regulated expression of annexin-II and β2-tubulin in C666-1 cells was also found to be lower in tumour cells than in adjacent normal epithelial cells of the NPC paraffin-embedded specimens [79], indicating that annexin-II and β2-tubulin might be potential targets for further NPC investigations. The gene discussed is ANXA2; the disease is nasopharyngeal carcinoma.