14-3-3σ, annexin-A3, annexin-A1, Heat-shock protein 105 kDa, Profilin-2, annexin-A5, etc., were up-regulated in PRA1-knockdown NPC cells; Protein S100-A4, Poly [ADP-ribose] polymerase 1, etc., were down-regulated in PRA1-knockdown NPC cells. This evidence concerns the gene RABAC1 and nasopharyngeal carcinoma.