MMP1 and cancer: For example, the SILAC labelling and combined fractional diagonal chromatography (COFRADIC) isolation of methionine-containing peptides allowed Andrea’s group to quantify differences in cancer-derived myofibroblasts compared to adjacent tissue-derived myofibroblasts, revealing an increased abundance of several proteases in cancer myofibroblasts, such as matrix metalloproteinases (MMP)-1 and -3 [41].