Keratin-8, keratin-19, α-enolase, annexin-A3, annexin-A1, and HSP27 were up-regulated in NPC; Vimentin, triosephosphate isomerase, superoxide dismutase, prohibitin, and Raf kinase inhibitor protein were down-regulated in NPC. The gene discussed is VIM; the disease is nasopharyngeal carcinoma.