CLIC1 and nasopharyngeal carcinoma: A Hollow Fibre Culture System is a strategy for secretory protein enrichment [81]; to discover sensitive and specific biomarkers of NPC, Liao’s group used the Hollow Fibre Culture System combined with HPLC-MS/MS for secretome analysis and found that chloride intracellular channel protein 1 (CLIC1) of secretory protein was highly expressed in NPC surgically removed samples but rarely expressed in non-NPC tissues [81].