CFTR and Gastrointestinal obstruction: Homozygous F508del-CFTR (CFTR∆F508) mice are susceptible to gastrointestinal obstruction and show consistent intestinal malabsorption that dramatically reduces body weight46, 48, 49, a significantly reduced intestinal cAMP-induced chloride and bicarbonate transport response46, 56, abnormal intestinal mucus secretion4, 57, a higher fecal biliary acids secretion46, 48, 49.