BRCA1 and breast cancer: The median age of diagnosis was 46 (range 29–63 years) in the 28 BC with a BRCA1 mutation (Table 3) and 45.5 (range 30–61 years) in the 11 BC with a BRCA2 mutation (Table 4), compared with a median age of diagnosis of 49.6 years (range 25–74 years) for the 161 cases without a mutation.