MAPK8 and brain inflammatory disease: In contrast, S. abortus LPS leads to preterm delivery that is associated with myometrial activation of both NF-κB and JNK/AP-1 and that inhibition of NF-κB by the cyclo-pentenone 15d-PGJ2 delays preterm delivery, improves pup survival and inhibits myometrial and brain inflammation in the mouse PTL model primarily (Pirianov et al. 2009).