We picked out the top five genes whose singlesiRNA perturbations had the lowest distance values relative to UC, namely, EZH2,UPF1, FOXM1, NUDT6, BAHD1 (distance value = 0.868,0.878, 0.883, 0.885, 0.891, respectively), and we investigated the mRNA levelsof these most likely candidate genes in the DSS-induced colitis mouse model byqPCR. The gene discussed is UPF1; the disease is colitis.