Among biological functions of protein lysine methylation in human cancer we previously categorized [6], this study implies that SUV39H2-mediated LSD1 methylation may increase the stability of LSD1 proteins by suppressing polyubiquitination, and may also alter LSD1-CoREST interaction, which causes aberrant transcriptional regulation of LSD1-downstream genes. Here, SUV39H2 is linked to cancer.