Additionally, lncRNAs, such as HOX transcript antisense intergenic RNA (HOTAIR), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1) and H19 play critical roles in the progression of glioma [5]. The gene discussed is HOTAIR; the disease is central nervous system cancer.