Simultaneous BCR-TLR9 activation induced the highest frequency of IL-10–producing B cells in HD (9.8 ± 3.3 %), as well as in patients with SLE (7.4 ± 3.0 %), which was consistent with the detection of secreted IL-10 (Fig. 1c). The gene discussed is BCR; the disease is systemic lupus erythematosus.