In addition, several studies have revealed that a member of the G-protein coupled receptor family, named GPR30 (also known as GPER), is also able to mediate estrogen signaling in diverse types of normal and malignant cells, including breast cancer cells and CAFs derived from breast tumor patients (Madeo and Maggiolini, 2010; Maggiolini and Picard, 2010). The gene discussed is GPER1; the disease is breast cancer.