CREB3L3 and steatosis: Specifically, females showed an increase in pparg and srebp1c, two genes that are known to be involved in activation and de novo lipogenesis, as well as the hepatic synthesis of fatty acid (Hsu and Huang, 2006; Tailleux et al., 2012; Yu et al., 2003), and a decrease in creb3l3, which has a protective role with regards to the development of steatosis (Zhang et al., 2012).