The recent discovery of several E3 ligases and deubiquitinases such as NEDD4-1, WWP2, XIAP, CHIP, SPOP, USP7 (HAUSP) and USP13 seems to imply that PTEN stability and subcellular localization are important in cancer development14, 16, 17, 18, 19, 20, 21. The gene discussed is USP7; the disease is cancer.