CXCL8 and Aicardi-Goutieres syndrome: Additional immune signaling genes (IL-33, CXCL3, CXCL1, IL-8, CCL11) were significantly up-regulated in at least one AGS sample (Supplementary file 2) and gene ontology analysis of AGS deregulated genes identified cytokine and chemokine signaling pathways as one of weakly enriched terms (Figure 1—figure supplement 1B).