In summary, we demonstrated that Fgl2 gene silencing inhibits apoptosis and improves heart function of STZ-induced diabetes rats, the possible mechanism maybe that Fgl2 gene silencing reduces the TNF-α levels, decreases the expression of bcl2, bax, TLR4 and p38 MAPK, but it has no effect on blood lipid. This evidence concerns the gene FGL2 and diabetes mellitus.