FGL2 and diabetes mellitus: With regard to EF and FS, both showed a trend toward gradual decline in the diabetic rats over the 12 weeks, with significant reductions (P< 0.05) after diabetes was induced and significant increase(P< 0.05) in Fgl2–RNAi gene silencing group compared with diabetes group (DM), diabetic empty vector group (DM-GFP; Table 2).