Consistent with the previously data, the protein and mRNA levels of PGC-1α in MAECs were decreased after DOCA-salt treatment (Supplementary Figures S2C and S2D), indicating that PGC-1α expression in endothelium may be negatively correlated with the development of hypertension induced by DOCA-salt. This evidence concerns the gene PPARGC1A and hypertensive disorder.