These indicators are critical for the prognostic outcome of MI, and their associated effects were especially noticeable in response to CR-SPRC compared with SPRC and captopril, with lower CK and LDH levels, reduced mortality and infarct size and better cardiac function, in addition to higher EF, FS and LVAWs and lower LVIDs, LVIDd, LVs and LVd. The gene discussed is SPRR3; the disease is myocardial infarction.