It is well established that obesity is accompanied with chronic inflammation, characterized by elevated proinflammatory cytokines like IL-6, TNF-α and IL-1β, as well as decreased IL-10 in circulation [4], and over-activation of inflammatory signal like NF-κB and JNK pathways in multiple cells like macrophages and adipocytes [5–7]. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.