Photoexcited hypericin exerts strong antigrowth activity in RINm5F insulinoma cells via inhibition of cell proliferation by reducing JNK/ERK phosphorylation and stimulation of apoptosis by elevating caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. The gene discussed is MAPK8; the disease is pancreatic insulinoma.