Using a hepatocyte-specific Hif2α knockout mouse, it was shown that in conditions of iron-deficiency HIF2α is not required for the repression of hepcidin, however mice with a constitutively active HIF2α (Vhlh/Hif1α double knockout mice) had lower hepcidin levels in their livers [89]. The gene discussed is HIF1A; the disease is Iron deficiency anemia.