Hryb et al showed that SHBG is produced by human PCa cells as well as cultured human prostate epithelial and stromal cells.27 Such observation would imply that SHBG may be locally regulated and produced, potentially having direct influence on carcinogenesis and/or progression of PCa independent of T. It can also be hypothesized that SHBG may additionally have indirect effects on carcinogenesis and/or progression of PCa. This evidence concerns the gene SHBG and posterior cortical atrophy.