SHBG and benign prostatic hyperplasia: Raivio et al observed that SHBG level was not significantly different between men with benign prostatic hyperplasia (BPH) and PCa.18 Also others reported similar findings on the association between SHBG level and presence of PCa.2,3,19 However, Grasso et al observed significantly higher SHBG level in PCa patients than those with BPH or healthy controls.13 Meanwhile, they could not confirm any association between SHBG and extent or stage of PCa and suggested that plasma-binding globulin is heterogenous.