Meanwhile, as others recently reported that SHBG, associated with poor clinical feature of PCa, is an important factor in stemness induction of cells by dihydroT in vitro, additional analyses on the expressions of various stemness related factors, such as Oct3/4 and Nanog, using tissues samples from RP specimens should be performed in the future.31 Overall, we believe that our findings warrant further investigation via a larger cohort of patients. This evidence concerns the gene NANOG and posterior cortical atrophy.