AR and cancer: Specific binding sites for SHBG on prostate cell membranes have been described.27 Also, it has been reported that SHBG can stimulate intraprostatic production of cyclic adenosine monophosphate (cAMP), and that androgen receptors in prostate can be activated by growth factors or cAMP.28 Thus, it can be hypothesized that SHBG increases the responsiveness of prostate epithelium to T, possibly leading up to carcinogenesis and/or cancer progression.