By comparing PCa patients with and without metastasis, Haapiainen et al reported that patients with metastatic disease showed significantly lower pretreatment T/SHBG ratio than nonmetastatic counterparts, whereas they observed no significant difference in T levels.20 From their findings, they mentioned that predictive value of T/SHBG ratio as a prognostic factor was higher than that of T level. This evidence concerns the gene SHBG and posterior cortical atrophy.