Meanwhile, data from genetic polymorphisms involved in metabolic pathways of sex hormones suggest that interindividual variations in genes associated with sex hormones could be related with PCa risk.29 Also, previous studies have shown that single-nucleotide polymorphisms (SNP) in SHBG gene were associated with serum T level as well as serum SHBG level.30 Accordingly, it can be hypothesized that polymorphisms in SHBG locus may be related to PCa aggressiveness. Here, SHBG is linked to posterior cortical atrophy.