ABCC8 and type 2 diabetes mellitus: For comparison, we also performed similar experiments in the SUR1 A1369 T2D susceptibility variant [2] and observed that diazoxide was still able to increase KATP current further in the presence of GTP (3.19±0.10 compared with 2.87±0.07; P<0.05; Figures 7C and 7D).