TP53 and hepatocellular carcinoma: Unlike some HCC cell lines which express the p53 mutant (Huh7) or have p53 deletion (Hep3B) [29], studies had confirmed that HepG2 cell processes a functional wild type p53 and activation of p53 in HepG2 cell could be used as novel approach to identify the genotoxic damage [30,31].