TP53 and cancer: Indeed, the three cell lines (MDA-MB-468, HT29 and A431) that were responsive to AKT de-phosphorylation, BMF induction and apoptotic cell death following p53-R273H depletion, express moderate to high levels of EGFR.58 Further work is indeed necessary to understand whether the role of mutant p53-R273H in the regulation of PI3K/AKT signaling and BMF expression influences metastatic development in human cancers.