Here we discovered that hypoxia impaired the formation of nuclear envelope and led prelamin A/C to localize inside of the nuclear lumen, mimicking the nuclear envelope in the HGPS patients.30 We also observed that early endosome localization of Rab5a was inhibited by hypoxia, and the hyperoxic conditions or mevalonate were able to reverse the inhibitory effect of the intracellular hypoxia. The gene discussed is RAB5A; the disease is Hutchinson-Gilford progeria syndrome.