TP63 and neoplasm: The TP63 gene contains two promoters that produce two proteins: the full-length TAp63 that contains functional N-terminal transcriptional transactivation (TA) domains and the ΔNp63 protein, which lacks TA domains.20 p63 has central roles in epithelial development and despite the two isoforms share some common features,20 TAp63 mainly acts as tumor suppressor and ΔNp63 as an oncogene.21, 22