Several studies suggest a tumor suppressor role for Sall2 in ovarian cancer3, 11, 12 and in primary acute myeloid leukemia.13 However, Sall2 is found upregulated in Wilm's tumor,14 synovial sarcoma,15, 16 oral cancer17, 18 and testicular cancer,19 and is one of the four neurodevelopmental transcription factors essential for glioblastoma propagation.4 The molecular mechanisms underlying the role of Sall2 as a tumor suppressor in certain types of cancer and its deregulation in others are still unknown. The gene discussed is SALL2; the disease is glioblastoma.