PMAIP1 and melanoma: Studies in HOSE cells showed that Sall2 represses MYC under etoposide treatment, or when Sall2 is overexpressed.21 On the other hand, MYC is an activator of the NOXA gene upon proteasome inhibitor treatment in melanoma and HeLa cells.48 The relationship between c-Myc, Sall2, and Noxa is not straightforward because studies are from different cell types and context.