In response to various types of stress, signaling pathways converge to induce transcriptional regulation by p53 of target genes involved in cellular responses including cell cycle arrest, apoptosis, senescence, autophagy, DNA repair and central metabolism.22, 23 p53 prevents tumor formation through transcriptional-dependent and -independent mechanisms.24, 25, 26 We recently demonstrated that SALL2 is also a p53 target gene. The gene discussed is TP53; the disease is neoplasm.