Consequently, loss of p53 and murine Sall2 synergistically promotes lymphomagenesis.13Sall2−/− or Sall2−/+; p53−/− mice, compared with the Sall2+/+;p53−/− mice, exhibit accelerated tumorigenesis and advanced tumor progression.13 All these results prompt further investigation to understand the regulatory and functional relationship between Sall2 and p53. Here, TP53 is linked to neoplasm.